GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9813712 | 1 | rs57804141 | chr3:129962512 | LOC729375 | chr3:129816625-129830276:- | 0.24 | 4.33 | 1.79E-5 | Response to amphetamines |
| THCA | cis | rs494003 | 1 | rs578056 | chr11:65514874 | CTSW | chr11:65647284-65651212:+ | -0.24 | -4.89 | 1.38E-6 | Systemic lupus erythematosus |
| THCA | cis | rs494003 | 1 | rs578056 | chr11:65514874 | RNASEH2C | chr11:65485146-65488409:- | -0.18 | -4.55 | 6.67E-6 | Systemic lupus erythematosus |
| THCA | cis | rs494003 | 1 | rs578056 | chr11:65514874 | SNX32 | chr11:65601410-65621170:+ | 0.39 | 5.18 | 3.35E-7 | Systemic lupus erythematosus |
| THCA | cis | rs2129782 | 1 | rs57807215 | chr8:89455068 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs7606754 | 1 | rs57817160 | chr2:228179238 | MFF | chr2:228189978-228222547:+ | 0.22 | 4.83 | 1.85E-6 | Corneal structure |
| THCA | cis | rs4534636 | 1 | rs57832572 | chr12:8668281 | CLEC4D | chr12:8666136-8674958:+ | 0.22 | 3.95 | 9.09E-5 | Response to radiotherapy in prostate cancer (toxicity, urinary frequency) |
| THCA | cis | rs935334 | 1 | rs57844481 | chr14:76684493 | ESRRB | chr14:76837690-76968178:+ | -0.33 | -5.05 | 6.33E-7 | Blood pressure |
| THCA | cis | rs7111546 | 1 | rs57862275 | chr11:22822055 | SVIP | chr11:22843600-22851382:- | 0.2 | 3.51 | 0.00049 | Dialysis-related mortality |
| THCA | cis | rs1027730 | 1 | rs57862518 | chr8:94070803 | C8orf83 | chr8:93895865-94029901:- | 0.27 | 4.43 | 1.19E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs1466662 | 1 | rs57866349 | chr4:155349420 | DCHS2 | chr4:155155527-155412930:- | 0.16 | 3.46 | 0.000595 | Alzheimer's disease (age of onset) |
| THCA | cis | rs6988636 | 1 | rs57902736 | chr8:124189893 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.31 | 1.99E-5 | Urinary uromodulin levels |
| THCA | cis | rs7818688 | 1 | rs57925408 | chr8:96062930 | C8orf38 | chr8:95908040-96088396:+ | -0.25 | -4.32 | 1.93E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs16958440 | 1 | rs57928699 | chr18:44645593 | HDHD2 | chr18:44633782-44676871:- | 0.26 | 4.98 | 8.99E-7 | Sitting height ratio |
| THCA | cis | rs16958440 | 1 | rs57928699 | chr18:44645593 | PIAS2 | chr18:44392061-44500123:- | -0.15 | -3.37 | 0.000804 | Sitting height ratio |